Toxicology and Carcinogenesis Studies of Rhodamine 6G (C.I. Basic Red 1) (CAS NO. 989-38-8) in F344/N Rats and B6C3F1 Mice (Feed Studies)

摘要

Toxicology and carcinogenesis studies were conducted by administering rhodamine 6G in feed to groups of 50 rats of each sex at doses, of 0, 120, or 250 ppm rhodamine 6G for 103 weeks. Groups of 50 male mice received diets containing 0, 1,000, or 2,000 ppm rhodamine 6G and groups of 50 female mice received diets containing 0, 500, or 1,000 ppm. Under the conditions of these 2-year feed studies, there was equivocal evidence of carcinogenic activity for male F344/N rats administered rhodamine 6G, as indicated by a marginally increased incidence of integumentary keratoacanthomas. There was equivocal evidence of carcinogenic activity for female F344/N rats administered rhodamine 6G, as indicated by a marginal increase in pheochromocytomas or malignant pheochromocytomas (combined) of the adrenal gland. There was no evidence of carcinogenic activity for male B6C3F1 mice administered 1,000 or 2,000 ppm rhodamine 6G in diet. There was no evidence of carcinogenic activity for female B6C3F1 mice administered 500 or 1,000 ppm rhodamine 6G in the diet.