What Causes Peak Splitting After Split, Splitless, or on Column Injection in Capillary Gas Chromatography

摘要

Split, splitless, and on-column are the most widely used sample-introduction modes in capillary gas chromatography. Under ideal conditions, solutes are eluted to the detector as short discrete bands, yielding sharp narrow peaks. Problems occasionally are encountered with sample introduction into the column. The paper discusses some solutions for problems related to injection technique, injection volume, sample solvents used, column position in the inlet, dirty inlets, thermal gradients, etc.