Ethylene Glycol Monomethyl Ether Reproduction and Fertility Assessment in C3H Mice When Administered in Drinking Water (Revised)

摘要

Ethylene glycol monomethyl ether (EGMME) severely affected fertility and reproduction in C3H mice when administered to adults at 0.3% in drinking water (none of the breeding pairs were fertile). At necropsy, body weights for both sexes, and seminal vesicles, right testis, right cauda and right epididymis weights in males were significantly decreased in the 0.3% dose group. The right ovary weight was relatively high. Sperm motility, sperm density and the incidence of abnormal sperm were also severely affected at 0.3% level. EGMME at 0.1% levels had less severe but still significant reproductive effects in the parental generation. There was no apparent effect on fertility or reproduction in F sub 0 or F sub 1 C3H mice at 0.03% level. Parental generation females in the 0.03% dose group showed slightly increased liver weights. In second generation animals, there was no effect with respect to terminal body or organ weights at the 0.03% level.