Review of Di(2-Ethylhexyl)Phthalate (DEHP) Risk Assessments.

摘要

Di(2-ethylhexyl)phthalate (DEHP) is the prototype compound of a class of compounds known collectively as the phthalate esters. Lifetime bioassays in rats and mice have indicated that DEHP produces liver tumors in these species when incorporated into the diet. The result has led governmental agencies and representatives of the private sector to attempt to estimate potential human cancer risks from exposure to DEHP and related phthalates in the environment. At least five such assessments have been conducted, each of which comes to a different conclusion regarding the magnitude of human cancer risks. In April 1988, the U.S. Environmental Protection Agency convened a workshop on DEHP risk assessment to compare five assessments of DEHP, to identify the reasons for the differences among them, and to discuss the use of pharmacokinetics and mechanistic information in the assessment of human health risk.