Introductions and Discontinuations of New Drugs in the United States and the United Kingdom, 1970-1988

摘要

The report presents a comparison of the relative rates of introduction and discontinuation of new molecular entities (NMEs) in the US and UK from 1970-88. During the period 417 NMEs were introduced on the two-country market, 334 in the UK and 279 in the US. Of the 417 NMEs, only 196, or 47% had been marketed in both countries. By the end of 1988, 33 of the UK NMEs and 19 of the US NMEs had been discontinued. The study breaks discontinuations into two groups, those associated with safety and those not associated with safety, and analyzes these groups within therapeutic class. Finally, using data from 1960-88, the report examines the rate of discontinuation by NME status whether a drug was marketed in only the US, only the UK, or in both countries. An appendix to the report contains the entire data base.