Appendix to Report No. 758474011. Integrated Criteria Document PAH: Republication of Addendum to Report No. 758474007, March 1989. Effects of 10 Selected Compounds

摘要

Polynuclear aromatic hydrocarbons (PAHs) are compounds consisting of carbon and hydrogen only, with two or more benzene rings in the molecule. The arenes and alkylated arenes belong to this group, whereas the aza-, imino-, nitro-, carbonyl-, oxa-, thio- and polychloro-arenes do not. The document, part of the Integrated Criteria Document PAH, consists of a detailed evaluation of the effects on man and environment of only 10 PAH, all belonging to the group of arenes. The given selection implies a severe restriction of the toxicological evaluation of PAH, which will be explained. Of all polynuclear aromatic compounds, the arenes are probably not the most harmful ones to man. Many arenes are known to be carcinogenic, however some nitro-arenes have been shown to have a much higher potency for causing genetic damage in mutagenicity tests than the arenes.