Final Report on the Reproductive Toxicity of Ethylene Glycol Monomethyl Ether (Cas No. 109-86-4) in Sprague-Dawley Rats, Litter Five

摘要

The purpose of the present study was to develop a 'Reproductive Assessment by Continuous Breeding' (RACB) protocol in CD Sprague-Dawley rats. Ethylene glycol monomethyl ether (EGMME), a known reproductive toxicant, was used as the test article. EGMME is a commonly used industrial solvent with well documented effects on the hemopoietic and reproductive systems. For instance, EGMME exposure via inhalation in rats, mice, and rabbits causes decreased thymus weights, decreased red and white cell counts, and other hemopoietic changes. Guinea pigs dermally exposed to EGMME exhibit decreased spleen weight and reduced red blood cell counts. There are many studies detailing EGMME's effects on the male reproductive system. Results of some of these studies are summarized.