Toxicology and Carcinogenesis Studies of alpha-Methylbenzyl Alcohol (CAS No. 98-85-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

摘要

Toxicology and carcinogenesis studies were conducted by administering alpha-methylbenzyl alcohol in corn oil by gavage at doses of 0, 375, or 750 mg/kg to groups of 50 rats and 50 mice of each sex 5 days per week for 103 weeks. Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity of alpha-methylbenzyl alcohol for male F344/N rats, as shown by increased incidences of renal tubular cell adenomas and adenomas or adenocarcinomas (combined). There was no evidence of carcinogenic activity for female F344/N rats administered 375 or 750 mg/kg. Renal toxicity characterized by severe nephropathy and related secondary lesions was observed in the dosed rats, and excessive mortality occurred during the last quarter of these studies. Poor survival reduced the sensitivity of the studies for detecting the presence of a carcinogenic response both in chemically exposed groups of male rats and in the high dose group of female rats. There was no evidence of carcinogenic activity of alpha-methylbenzyl alcohol for male or female B6C3F1 mice administered 375 or 750 mg/kg for 2 years.