Application of 5,10-Methylene Tetrahydrofolate Models in Alkaloid Synthesis

摘要

The 5,10-methylene tetrahydrofolate (5,10-CH(2)-FH(4)) models have shown themselves to be versatile reagents in the synthesis of complex organic molecules. The purpose of the work presented in the thesis was to investigate and to expand the scope of the functionalized carbon fragment transfer reaction with 5,10-CH(2)-FH(4) models. For this purpose the construction of the aspidosperma skeleton, and the syntheses of the benzo- and indoloquinolizine alkaloids have been investigated. Enantioselective synthesis, starting from optically active material, with the 5,10-CH(2)-FH(4) models has also been evaluated.