Chemoprotection against Cisplatin Nephrotoxicity: A Molecular Approach withSelenium Compounds

摘要

The investigations described in the thesis are primarily concerned with studieson the effects of selenium compounds on the nephrotoxicity of cisplatin and studies on the molecular mechanisms involved. Sodium selenite was chosen as model compound, because selenite is an anti-oxidant and selenite can be activated to nucleophilic metabolites (Ganther, 1971). Both anti-oxidants and nucleophilic agents have been shown to protect against cisplatin-induced nephrotoxicity. Attempts were made to gain insight into the molecular mechanisms of the effects of sodium selenite on the nephrotoxicity of cisplatin, with the primary aim to use the obtained knowledge to select the most appropriate selenium compound for further preclinical testing. (Copyright (c) G. S. Baldew, Delft, 1990.)