Carbon Tetrachloride Metabolism in Partially Hepatectomized and Sham-Operated Rats Pre-Exposed to Chlordecone (Kepone)

摘要

The potentiation of CCl4 toxicity by pre-exposure to chlordecone (CD) is well established. Chlordecone-induced metabolism of CCl4 and suppressed hepatocellular repair have been offered as possible mechanisms for this potentiation. The present study was initiated to determine if metabolism and disposition of (14)CCl4 is altered in the PH rat, and if this is a contributing factor to the reported protective effect afforded by the PH procedure. The rats were challenged with a single dose of CCl4 (100 microliters/kg, ip) containing 20 micro Ci(14)CCl4. Lipid peroxidation and serum enzyme activities (aspartate aminotransferase (AST) and alanine aminotransferase (ALT)) were measured as indices of toxicity. (Copyright (c) 1989 VCH Publishers, Inc.)