Health Hazard Evaluation Report HETA 90-390-2065 and MHETA 86-012-2065, R. T.Vanderbilt Company, Gouverneur, New York and NIOSH Comments to OSHA on 'Variations in the Carcinogenicity of Tremolite Dust Samples of Differing Morphology'

摘要

The testimony concerned the comments of NIOSH on a manuscript entitled Variationsin the Carcinogenicity of Tremolite (77536686) Dust Samples of Differing Morphology. In general the results presented in the publication have not been peer reviewed or published in the scientific literature and therefore NIOSH suggested they be viewed with caution. Appropriate controls were not included in the study, the material and methods section lacked sufficient detail to evaluate the results, and the results were presented in an awkward and confusing way. The interpretation of results for the evidence of carcinogenicity in two of the samples was questionable. Mineralogic classification of the various samples, particularly three of the samples, was unclear. To what degree the nonasbestiform varieties of tremolite used in the study represent other varieties in the world was not clear. Dose response relationships associated with fibers from these tremolite samples were not able to be developed. In general, the results appeared to demonstrate that all forms of tremolite asbestos should be considered carcinogenic.