Cotinine Analytical Workshop Report: Consideration of Analytical Methods for Determining Cotinine in Human Body Fluids as a Measure of Passive Exposure to Tobacco Smoke

摘要

A two day technical workshop was convened in November, 1986 to discuss analytical approaches for determining trace amounts of cotinine in human body fluids resulting from passive exposure to environmental tobacco smoke (ETS). The workshop, jointly sponsored by the US EPA and CDC, was attended by invited scientists with expertise in cotinine analytical methodology and/or conduct of human monitoring studies related to ETS. The workshop format included technical presentations, separate panel discussions on chromatography and immunoassay analytical approaches, and group discussions related to the quality assurance/quality control (QA/QC) aspects of future monitoring programs. The report presents a consensus of opinion on general issues before the workshop panel participants and also a detailed comparison of several analytical approaches being utilized by the various represented laboratories. The salient features of the chromatography and immunoassay analytical methods are discussed separately.