Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) inF344/N Rats and B6C3F1 Mice (Drinking Water Studies)

摘要

Groups of 80 F344/N rats and B6C3F(1) mice of each sex received 0 or 175 ppmsodium fluoride and groups of 50 rats and mice of each sex received 25 or 100 ppm sodium fluoride in deionized drinking water ad libitum for up to 103 weeks. Under the conditions of these 2-year dosed water studies, there was equivocal evidence of carcinogenic activity of sodium fluoride in male F344/N rats, based on the occurrence of a small number of osteosarcomas in dosed animals. 'Equivocal evidence' is a category for uncertain findings defined as studies that are interpreted as showing a marginal increase of neoplasms that may be related to chemical administration. There was no evidence of carcinogenic activity in female F344/N rats receiving sodium fluoride at concentrations of 25, 100, or 175 ppm (11, 45 or 79 ppm fluoride) in drinking water for 2 years. There was no evidence of carcinogenic activity of sodium fluoride in male or female mice receiving sodium fluoride at concentrations of 25, 100, 175 ppm in drinking water for 2 years. Dosed rats had lesions typical of fluorosis of the teeth and female rats receiving fluoride had increased osteosclerosis of long bones.