Mutagenicity, Carcinogenicity, and Human Cancer Risk from Indoor Exposure to Coaland Wood Combustion in Xuan Wei, China

摘要

The residents in Xuan Wei County, China, have been exposed to high levels ofcombustion emissions from smoky and smokeless coal and wood combustion under unvented conditions in homes. An unusually high lung cancer mortality rate that can not be attributed to tobacco smoke or occupational exposure was found. The communes using smoky coal, which emits more organics than smokeless coal, generally have a higher lung cancer rate than the communes using smokeless coal or wood. The mutagenicity and carcinogenicity of organic extracts of indoor air particles collected from Xuan Wei homes during cooking were investigated. The objectives of the study were (1) to investigate the characteristics of lung cancer mortality in Xuan Wei, (2) to determine the genotoxicity and chemical and physical properties of the combustion emissions, and (3) to link bioassay results to human lung cancer data. The organic extracts of these emission particles were