Gonadotrophins for Induction of Ovulation Immunological, Pharmacological and Clinical Studies

摘要

Induction of ovulation with gonadotrophins has been practiced for many years by gynecologists and endocrinologists. In Chapter 1 a review concerning the dependence of ovarian function on gonadotrophins in the normal human female and its application in infertile women suffering from anovulation is given. Chapter 2 describes the development of a CBA for FSH based on the induction of granulosa cell DNA synthesis. In Chapter 3 the assay is applied to IgG purified from serum of a young girl presenting with gonadotrophin independent precocious puberty. In Chapter 4 the CBA is applied to IgG preparations purified from the serum of fourteen patients with premature ovarian failure (POF). Chapter 5 compares the pharmacodynamic, pharmacokinetic and clinical properties of FSH and hMG during induction of ovulation in hypogonadotrophic women. Chapter 6 describes the pharmacodynamic, pharmacokinetic and clinical results of FSH and hMG during induction of ovulation in eumenorrheic women in whom endogenous gonadotrophin secretion was suppressed by high frequency iv administered LHRH. Chapter 7 describes the pharmacokinetic and pharmacodynamic properties between FSH and hMG in clomiphene resistant PCOD women treated for anovulation. Chapter 8 contains the clinical results of the double blind comparative study described in Chapter 7.