Final Report on the Reproductive Toxicity of 2-Hydroxy-4-Methoxybenzophenone (CASNo. 131-57-7) in CD-1-Swiss Mice

摘要

2-Hydroxy-4-methoxybenzophenone, (HMBP), a common ingredient in sunscreens andtanning agents, was tested for its effects on fertility and reproduction in Swiss CD-1 mice according to the Continuous Breeding protocol. It was administered via feed. Based on results of a dose-finding study, 1.25, 2.5, and 5.0% (w/w) were chosen to investigate effects on fertility and reproduction. Male and female mice were continuously exposed for a 7-day precohabitation and a 98-day cohabitation period (Task 2). Based on the results of the present study, it is concluded that HMBP causes systemic toxicity but has minimal effects on fertility and reproduction at these doses.