Toxicology and Carcinogenesis Studies of l-Epinephrine Hydrochloride (CAS No. 55-31-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

摘要

Toxicology and carcinogenesis studies of 1-epinephrine hydrochloride wereconducted by exposing groups of 60 rats of each sex to aerosols of 1-epinephrine hydrochloride at concentrations of 0, 1.5, or 5 mg/cu m, 6 hours per day, 5 days per week for 103 weeks. Groups of 60 mice of each sex were exposed to 0, 1.5, or 3 mg/cu m 1-epinephrine hydrochloride, 6 hours per day, 5 days per week for 104 weeks. Under the conditions of these studies, no carcinogenic effects were observed in male or female F344/N rats exposed to aerosols containing 1.5 or 5 mg/cu m 1-epinephrine hydrochloride for 2 years. However, these studies were considered to be inadequate studies of carcinogenic activity because the concentrations used, which were chosen to represent multiples of human therapeutic doses, were considered too low for animals to have received an adequate systemic challenge from the compound.