Final Report on the Developmental Toxicity of Butyl Benzyl Phthalate (CAS No. 85-68-7) in CD-1-Swiss Mice

摘要

Butyl benzyl phthalate (BBP) is a phthalate acid ester (PAE) plasticizer ofpolyvinyl chloride resins used in the manufacture of vinyl flooring, adhesives, sealants and food packaging. Animal studies indicate that exposure to BBP can result in testicular and hepatic toxicity. The current study in mice, as well as a companion study in rats were undertaken because of the potential for exposure of pregnant women to BBP, the known teratogenicity of other PAEs and the lack of information about the developmental toxicity of BBP in mammals. In the study, timed-pregnant mice were administered BBP in feed during organogenesis, and evaluations were made of maternal toxicity and effects on embryo/fetal viability, growth and morphogenesis.