Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CAS No. 1271-19-8) in F344/N Rats (Gavage Studies)

摘要

Toxicology and carcinogenesis studies of titanocene dichloride were conducted byadministering the chemical at doses of 0, 25 or 50 mg/kg in corn oil by gavage to groups of 60 F344/N rats of each sex for 5 days a week for 104 weeks. Under the conditions of these 2-year gavage studies, there was equivocal evidence of carcinogenic activity of titanocene dichloride in male F344/N rats based on a marginal increase in the incidence of forestomach squamous cell papillomas, squamous cell carcinoma and basosquamous tumor benign. There was equivocal evidence of carcinogenic activity of titanocene dichloride in female F344/N rats based on a marginal increase in the incidence of forestomach squamous cell papillomas. Nonneoplastic lesions associated with the administration of titanocene dichloride for up to 2 years included erosions and inflammation of the gastric mucosa, hyperplasia and metaplasia of the fundic glands with fibrosis of the lamina propria in the glandular stomach, and acanthosis (hyperplasia and hyperkeratosis of the forestomach epithelium).