SAB Report: Evaluation of EPA'S Research on Expert Systems to Predict the Fateand Effects of Chemicals

摘要

This report presents the conclusions and recommendations of the U.S.Environmental Protection Agency's Science Advisory Board following a review of research in progress on 'Expert Systems for Predicting the Environmental Fate and Effects of Chemicals'. Three research programs were reviewed. SPARC is an expert system for estimating chemical and physical reactivity. CRAMS predicts reactivity parameters of organic chemicals from spectroscopic data. The QSAR has several expert systems within it, but for this review, the Subcommittee concentrated on the 'Single Integrated Language for Chemicals' and the plans for predicting mechanisms of toxic action from chemical structure. The Subcommittee supports the continued development and vigorous testing of each system. The SPARC and QSAR systems were considered state-of-the-art.