Toxicity Studies of D and C Yellow No. 11 (CAS No. 8003-22-3) in F344/N Rats andB6C3F1 Mice (Feed Studies)

摘要

Toxicity studies were conducted by administering D&C Yellow No. 11 (approximately99% pure) in feed at dietary concentrations of up to 50,000 ppm to groups of F344/N rats and B6C3F1 mice of each sex for 14 days or 13 weeks. A separate study was conducted to determine the effects of feeding diets containing D&C Yellow No. 11 to female rats during a reproductive cycle and to their offspring. Although the estimated intake of D&C Yellow No. 11 by mice was more than twice that by rats, the results of the 14-day and 13-week studies were similar for both rats and mice. In both species, D&C Yellow No. 11 caused no deaths (5 animals per group in the 14-day studies and 10 per group in the 13-week studies) but did reduce body weight gain slightly in rats of each sex exposed to 17,000 or 50,000 ppm. Liver weights were increased in dosed rats and mice. There was minimal-to-mild degeneration of the periportal portion of the liver lobules of rats at dietary concentrations of 1,700 ppm and higher and of mice at 5,000 ppm and higher. In a perinatal toxicity study, body weight gain of rat dams given diets containing as much as 50,000 ppm D&C Yellow No. 11 for 4 weeks before mating to unexposed males was similar to that of controls at the time of mating but was lower at parturition and weaning. The results of these studies indicate that compound-related effects occurred at all dietary concentrations of D&C Yellow No. 11; i.e., liver weights were increased in dosed rats and mice, and there was an increase in the number and size of hyaline droplets in all dosed groups of male rats.