Final Report on the Reproductive Toxicity of Tris(2-Chloroethyl)phosphate Reproduction and Fertility Assessment in Swiss CD-1 Mice When Administered via Gavage

摘要

Tris(2-chloroethyl)phosphate (TCEP) is one of the class of tris organophosphates. It is used as a flame-retardant for plastics and synthetic fibers. TCEP was tested for its effects on fertility and reproduction in Swiss CD-1 mice according to the Continuous Breeding Protocol. It was administered via gavage. Based on results of previous data and a dose-finding study, 175, 350, and 700 mg/kg bw were chosen to investigate effects on fertility and reproduction.