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Concentration of Glial Fibrillary Acidic Protein Increases with Age in the Mouse and Rat Brain

机译:胶质纤维酸性蛋白的浓度随着年龄的增加而增加

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The role of aging in the expression of the astrocyte protein, glial fibrillary acidic protein (GFAP), was examined. In both mice and rats the concentration of GFAP increased throughout the brain as a function of aging. The largest increase (2-fold) was observed in striatum for both species. The neuron-specific proteins, synapsin I and neurofilament-200 were not altered by aging in any region of the mouse or rat brain. The data suggest that strocytic hypertrophy observed with aging involves an accumulation of glial filaments.

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