Mechanisms of Aldehyde-Induced Bronchial Reactivity: Role of Airway Epithelium

摘要

The purpose of the study was to determine whether exposures to environmentallyrelevant concentrations of two aldehydes of low molecular weight were associated with impaired airway function. Specifically, the study addressed questions of the relative irritant potency of formaldehyde and acrolein on the induction of increased bronchial reactivity to acetylcholine in guinea pigs. The relationship of bronchial reactivity to epithelial damage and inflammation were also examined after both in vivo and in vitro exposures.