Investigation of the Effects of Activity and Environment on Atabrine Therapy

摘要

The purposes of the research were (1) To determine with each of two recommended suppressive regimens administered to troops during active training: (a) the time required to develop equilibrium plasma atabrine levels; (b) the magnitude of the level in relation to dosage and (c) the variability in levels among individuals on the same regimen. (2) To determine the effect of high initial doses in shortening the time required to reach equilibrium levels. (3) To determine the effects of a simulated jungle climate upon the plasma atabrine levels. (4) To study the rate of reduction of plasma atabrine levels after discontinuing administration of the drug. (5) To study the relationship between the plasma atabrine levels obtained with therapeutic doses and those established previously with suppressive regimens. (Author)