Mutagenic Screening of Six Candidate Dyes for Colored Smoke Munitions in the Salmonella Reversion Assay

摘要

Three red dyes, Amoplast Red PC, Macrolex Red 1069, and Oil Red G, and three violet dyes, Macrolex Violet B, Macrolex Violet 3R, and Resiren Violet TR were tested for mutagenic potential in the Salmonella reversion assay without and with metabolic activation by post-mitochondrial liver fractions induced with Aroclor or phenobarbital. The dyes which gave clearly positive mutagenic responses in the bacterial assay were Macrolex Red 1069, Amoplast Red PC, Resiren Violet TR, and Macrolex violet B. The increase in revertants was observed in those strains responsive to frameshift mutagens, TA1537, TA1538, and TA98. One dye was also active when tested with TA100 which can also detect frameshift mutagens.