Correlation of Mutagenic, Carcinogenic and Co-Carcinogenic Effects of Chemical Substances. Granuloma Pouch Assay

摘要

The research project is concerned with the detection of premalignant and malignant cells induced in vivo in a novel assay system the granuloma pouch assay. Cells exposed to carcinogens in vivo can be studies for DNA damage, chromosomal aberrations, specific locus mutations and cell transformations. Various assays were developed to investigate the growth characteristics of normal, carcinogen-exposed and transformed granuloma pouch cells.