COSMOS 936, experiment K204: The effects of space flight on some liver enzymes concerned with carbohydrate and lipid metabolism in the rat

摘要

The activities of about 30 enzymes concerned with carbohydrate and lipid metabolism and the levels of glycogen and of the individual fatty acids in hepatic lipids in rat livers exposed to space flight conditions were examined. Statistically significant decreases in the activity levels of glycogen phosphorylase, alpha-clycerol phosphate acyl transferace, diglyceride acyl transferace, aconitase, and 6-phosphoglocomate dehydragenase were noted in the weightless group. All enzyme activities returned to normal 25 days postflight. When the liver glycogen and the total fatty acids of the flight animals were determined, significant differences that could be attributed to reduced group at recovery contained more than twice the amount of glycogen than did the centrifuged controls and a remarkable shift in the ratio of palmitate to palmitoleate was noted.