Genetic Evaluation of dow Corning X2-7551 Intermediate (cyclosiloxanes, Di-me) in Bacterial Reverse Mutation Assays with Cover Letter dated 04/20/94.

摘要

This study evaluated the mutagenic potential of dimethyl cyclosiloxane fluid in the Salmonella typhimurium and Escherichia coli Reverse Mutation assays as described in O.E.C.D. Guidelines (CRF 46(162)). Mutagenicity was evaluated by measuring the ability of the test substance to produce reverse mutations in several strains of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and Escherichia coli (WP2) in both the presence and absence of Aroclor- induced rat liver microsomal enzymes. Five concentrations of test substance (312.5, 625, 1250, 2500, or 5000 ug/plate), were plated with each tester strain in the presence or absence ofmicrosomal enzymes. Sodium azide, 9-amino acridine, n-methyl-n- nitrosoguanidine, 2-anthramine, and 2-nitrofluorene served as positive controls. Results were presented as the number of revertants per plate. No mutagenic responses were produced by the test substance in any strain tested in the absence or presence of microsomal enzymes.