Acute Inhalation Toxicity Study in Rats with Sc-3950 (tetramethyldivinyldisiloxane). Final Report (revised).

摘要

THE TEST MATERIAL, SC-3950 WAS EVALUATED FOR ACUTE INHALATION TOXICITY IN RATS. THE EXPOSURE OF TEN RATS EACH TO SC-3950 AT NOMINAL CONCENTRATIONS OF 248.03, 211.90,111.47, AND 22.63 MG/L CAUSED VARYING DEGREES OF EYE, NASAL AND MUZZLE IRRITATION, IRREGULAR BREATHING, CONVULSIONS, PROSTRATION AND DEATH. AT THE 248.03 AND 211.90 MG/LITER LEVELS ALL OF THE RATS EXPOSED DIED. AT 111.47 MG/LITER SIX OUT OF TEN RATS DIED DURING EXPOSURE AND TWO WITHIN ONE HOUR AFTER EXPOSURE. AT THE 22.63 MG/LITER LEVEL, THERE WERE ONLY MINOR SIGNS OF TOXICITY AND NO DEATHS. THE LC50 (ONE HOUR) OF SC-3950 AEROSOL APPEARS TO BE BETWEEN 111.47 AND 22.63 MG/LITER.