Acute Dermal Toxicity (single Exposure) of Fluoropropylmethylcyclotrisiloxane in Rabbits.

摘要

THE TEST SUBSTANCE, 449-2595-2 (88571) LOT # BB001, WAS EVALUATED FOR ITS POTENTIAL TO PRODUCE SYSTEMIC TOXICITY OR DEATH FOLLOWING TOPICAL APPLICATION AT DOSE LEVELS OF 20.0, 10.0, AND 2.0, G/KG TO MALE AND FEMALE ALBINO RABBITS. BASED UPON THE MORTALITY AND THE CRITERIA OF THE STUDY PROTOCOL, THE ESTIMATED LD50 IS 25.4 G/KG (95% CONFIDENCE LIMITS - LOWER 7.1 G/KG, UPPER 90.8 G/KG). THIS STUDY WAS CONDUCTED TO EVALUATE THE VALIDITY OF AN EARLIER STUDY USING THESE DOSES WHICH INDICATED