Reproductive toxicological aspects of chromium in males

摘要

To expand our present understanding of the effects of chromium on male fertility a number of studies were designed to achieve this through the use of chromium intoxicated experimental animals and through investigation of sexual hormones and sperm quality in welders. Also in view of the lack of an experimental model for effects of noxious substance on the epididymal spermatozoa the main objectives of the series of studies reviewed here were: A. To establish a model for evaluation of epididymal sperm count and motility in the rat. B. To investigate and compare the effects of tri- and hexavalent chromium on epididymal spermatozoa. Further to describe the effects of low-dose long-time exposure of rats to the most toxicological interesting chromium oxidative state - hexavalent chromium. C. By the use of autoradiography and (gamma)-countinuing to expand the present knowledge on the distribution of chromium in the body with special reference to the male reproductive organs. D. To describe the effects of exposure to hexavalent chromium in welding fume on levels of sexual hormones and semen parameters in welders. (EG). (Atomindex citation 27:007880)