We have demonstrated a non-contact method of concentrating and mixing particles in a plastic microfluidic chamber employing acoustic radiation pressure. A flaw cell package has also been designed that integrates liquid sample interconnects, electrical contacts and a removable sample chamber. Experiments were performed on 1, 3, 6, and 10(micro)m polystyrene beads. Increased antibody binding to a solid-phase substrate was observed in the presence of acoustic mixing due to improve mass transport.
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