Letter from Shell Oil Company to USEPA Concerning Copies of Slides Presented at the 091086 Meetings Concerning the Subchronic Studies with Attachments.

摘要

Summary toxicokinetic and toxicity information regarding glycol ethers is presented. Comparative in vitro absorption rates of glycol ethers through human epidermis ranged from 22.2 ug/sq cm/hr (for triethylene monobutyl ether) to 2705 ug/sq cm/hr (for ethylene monomethyl ether). In a dermal limit test with rabbits, each glycol ether was administered at 1 g/kg under occlusion to shaved backs of rabbits for 6 hrs/day, 5 days/week for 3 weeks. No toxic effects were noted other than irritation at the site of application. CMA briefly outlined a proposed subchronic dermal toxicity study with rabbits of triethylene glycol methyl ether.