Evaluation of P-chlorobenzotrifluoride in the in Vitro Transformation of Balb/3t3 Cells Assay (final Report).

摘要

The ability of p-chlorobenzotrifluoride to induce morphological transformation was evaluated in Balb/3T3 mouse cells (Cell Transformation Assay). Based on preliminary toxicity determinations (exposure time = 72hrs), p-chlorobenzotrifluoride, was tested at concentrations of 0.1, 1.0, 10.0, 20.0 and 40.0nl/ml, resulting in a range of 80% to 50% relative survival. None of the applied concentrations resulted in the induction of any transformed foci, while the positive control (MCA) resulted in 38 transformed foci showing that the sensitivity of the assay was normal.