Optical Measurement of Photosensitizer Concentration Using a Probe with a smallsource-detector separation

摘要

We present a novel minimally invasive method to measure the concentration ofphotodynamic therapy drugs in real time. The method is based on measurements of backscattered and fluorescence light using a steady state fluorescence spectrometer. The ratio of the fluorescence to scattered light is found to be linearly proportional to the absorption coefficient of the photosensitizer. The fiber-optic probe used for the measurements has a small source-detector separation, therefore the measurements could be performed through the working channel of an endoscope.