New Synthesis of TATB. Scaleup and Product Characterization.

摘要

At the 29th International Annual Conference of ICT (1998), the authors described the results of laboratory-scale process development studies for a new synthesis of 1,3,5-triamino- 2,4,6-trinitrobenzene (TATB). Thisnew synthesis approach--which uses vicarious nucleophilic substitution (VNS) methodology--converts picramide to TATB in high yield, and potentially at lower cost and with few environmental effects than existing synthetic approaches. In this report they describe results of their work on producing TATB by the VNS method at the pilot plant scale.They will discuss structure and control of impurities, changes in yield/quality with reaction conditions, choice of solvents, workup and product isolation, safety, and environmental considerations. Product characterization (particle size, DSC, HPLC, etc.) as well as small-scalesafety and performance testing is also discussed.