Effects of temporal modeling on the statistical uncertainty of spatiotemporaldistributions estimated directly from dynamic SPECT projections

摘要

Artifacts can result when reconstructing a dynamic image sequence frominconsistent single photon emission computed tomography (SPECT) projections acquired by a slowly rotating gantry. The artifacts can lead to biases in kinetic parameters estimated from time-activity curves generated by overlaying volumes of interest on the images. To overcome these biases in conventional image based dynamic data analysis, we have been investigating the estimation of time-activity curves and kinetic model parameters directly from dynamic SPECT projection data by modeling the spatial and temporal distribution of the radiopharmaceutical throughout the projected field of view.