Signaling to the p53 Tumor Suppressor through Pathways Activated by Genotoxic and Non-genotoxic Stresses

摘要

The p53 tumor suppressor is a tetrameric transcription factor that is post-translational modified at(approx)18 different sites by phosphorylation, acetylation, or sumoylation in response to various cellular stress conditions. Specific posttranslational modifications, or groups of modifications, that result from the activation of different stress-induced signaling pathways are thought to modulate p53 activity to regulate cell fate by inducing cell cycle arrest, apoptosis, or cellular senescence. Here we review the posttranslational modifications to p53 and the pathways that produce them in response to both genotoxic and non-genotoxic stresses.