THE RENEWAL OF NUCLEOTIDES AND NUCLEIC ACIDS IN THE C57 MOUSE STUDIED WITH ADENINE-4, 6-C ︳4

摘要

Adenine has been shown to be extensively utilized for the formation of acid-soluble adenine nucleotides and for the formation of RNA and DNA in the C57ouse. The "apparent half lives" of the adenine in the nucleotides, RNA, and DNA of the organs of the mouse have been calculated, and a "fast" and a "slow"-component adenine were found in the adenine-containing fractions in several tissues. Evidence is presented that soluble adenine;nucleotides serve as precursors for RNA and DNA, and that the equilibration of nucleotides with RNA is relatively rapid in the large and small intestines and probably also in the bone marrow. The desirability of more extensive data for nucleotide and nucleic acid specific activity as a function of time with several precursors including adenine, formate, glycine, 4-amino-5-imidazolecarboxamide, and phosphate is emphasized.