Metabolism of Radioactive Strontium in Rat PARTⅠ. THE WHOLE-BODY RETENTION AND TISSUE DISTRIBUTION CHARACTERISTICS OF Sr-85 PARTⅡ. ATTEMPTS TO INFLUENCE ELIMINATION BY PHYSIOLOGICAL AND OTHER PROCEDURES

摘要

A satisfactory method of whole-body counting of Sr-85 in small experimental animals has been devised along with methods for analysis of excreta and tissues. Use of rats of bodyweight between 150 and 200 g is convenient and ensures reproducible body retention characteristics. Analysis of tissues from animals sacrificed at intervals following administration of Sr-85 shows a rapid clearance from soft tissues and uptake into bone tissue in a matter of hours. This underlines the need for early therapy if attempts at removal are to be simple and effective. Any alternative approach will necessarily involve modification of basic physiological parameters affecting bone metabolism. Distribution in tissues over a 4-8 hour period was analyzed in more detail than has been reported hitherto.