AN ANALYSIS OF THE CARCINOGENIC RISK FROM AN INSOLUBLE ALPHA-EMITTING AEROSOL DEPOSITED IN DEEP RESPIRATORY TISSUE:ADDENDUM

摘要

Several experiments are reviewed in¬volving skin and lung carcinogenesis in mammals after intense localized doses of ionizing radiation. A high incidence of cancer occurs for the exposures described. The observations suggest that the car¬cinogenesis is primarily mediated by in¬jury or disruption of local tissue. It is concluded that there is a substantial possibility of enhanced cancer risk associ¬ated with the deposition of intense α-emitting particulates in deep respiratory tissue. Within this description lung cancer risks as high as 10-3 to 10-4 per disruptive source particle are indicated.