Specificity of Increased Resistance of Animals to Repeated Action of Renal Poisons

摘要

Rabbits and rats were subjected to a repeated and mixed uranium and mercuric chloride poisoning. Investigations of the concentration of residual nitrogen in the blood revealed that increased resistance of the animals to repeated poisoning occurred only when the same renal poison-uranium or mercuric chloride was administered repeatedly. In the experiment with the mixed poisoning by different renal poisons the sensitivity of the animals to repeated poisoning did not change. The level of residual nitrogen in the blood increased after each poisoning independent of the consecutiveness of the introduction of uranium and mercuric chloride. By the anaphylaxis reaction and desensitization, antigens missing in normal animals appeared in the kidney and liver tissues of experimental animals. (ERA citation 07:055251)