83RBAND 137CS METABOLISM IN PERSONS AFFECTED BY MUSCLE DISEASE

摘要

Comparison of the 83Rb and 137Cs activity in blood,, urine, and the total-body at common times after administration showed that although kidney clearance of both Rb and Cs from the plasma was similar in diseased and healthy subjects of corresponding age and sex, the fraction of retained, total-body 13Rb and 137Cs circulating In the plasma was significantly greater in diseased subjects. Partitioning of Rb and Cs between red cells and plasma was similar for ell subjects. These flndlj.gs of distinctive retention patterns, Increased excretion, but normal kidney function, and normal erythrocyte-to-plasma ratios In diseased persons are consistent with the concept that a cellular defect, resulting in altered membrane permeability |n some eel Is, may account for the enhanced elimination of Rb and Cs In persons with muscular dystrophy.