DEVELOPMENT OF A DIAGNOSTIC MODEL FOR INHALED PROMETHIUM-147 ANIMAL STUDIES

摘要

Rats and beagle dogs were exposed by inhalation to an aerosol containing stable Sm203 tagged with l45Sm203 and 143Pm203. The animals were sacrificed at 0, 14 and 30 days post-exposure to compare the kinetics and translocation of l45Sm and l43Pm.nQuantitative analysis for l45Sm and l43Pm in several tissues and excreta indicate that the two rare earth elements were mobilized and distributed similarly by the rats and dogs. Results indicate that within the error of the measurement technique, samarium acts as a carrier for promethium. The data also indicate that activities measured in fecal samples could be used to pre¬dict lung burdens of 147Pm.nAt activity levels and sintering temperatures employed in the rat exposures, there was sufficient activity in urine samples to permit its use as an indicator of lung burdens of l47Pm. At activity levels and sintering temperatures employed in the dog exposures, this was not the case.