Yield of Chromosomal Aberrations and Recoil Particle Range in Chineses Hamster Fibroblasts Exposed to 8.5 to 500 Kev Neutrons

摘要

Induction of chromatid aberrations in S-phase Chinese hamster fibroblasts has been studied for irradiation by exp 60 Co gamma rays and neutrons of average energy 8.5, 45, 83, 200 and 500 keV. At 10 per cent aberration level the relative biological afficiency varied between 2.2 +- 0.6 (at 8.5 keV) and a maximum of 47 +- 9 (at 200 keV). The neutron generated recoils have short range in comparison to chromosomal dimensions. The strong variation with neutron energy is therefore not necessarily reflecting variations in the average linear energy transfer. Good agreement between experimental and predicted response was obtained when effects ascribed to range were considered. A critical volume within which primary lesions should occur in order to make chromosomal aberrations probable was derived. The corresponding site radius was estimated to be 1-3 mu m. (Atomindex citation 08:330288)