Dose-Response Curves from Incomplete Data

摘要

A procedure is described which uses the now classical Kaplan-Meier estimator to establish dose-response curves from incomplete data under the assumption that the different observed responses are statistically independent. It is pointed out that for incomplete data the shape of the dose-response curve is undecidable in some situations. An example given using actual data to illustrate the estimation procedure is the dose-response curve for beagles that received injecions of exp 226 Ra and exp 228 Th. (ERA citation 03:055914)