Leukemia Accelerating (LAc) Properties of Retroviruses in AKR, SJL and CBA/H Mice

摘要

Retrovirus expression was studied in eight spontaneous lymphomas of SJL mice. We showed that viruses were present in all of the tumors; some N-tropic, some B-tropic and, in one instance, xenotropic viruses were found. Two of these virus preparations accelerated thymic lymphoma after inoculation of neonatal SJL mice. Cells from normal lymphohemopoietic tissues of 6-week-old AKR, SJL, and CBA/H mice were also evaluated for retrovirus expression. Viruses were found in all AKR and SJL tissues but not in those from CBA/H mice. In additional experiments, four AKR-derived viruses which were leukemia accelerating for AKR mice were tested by inoculation into neonatal SJL and CBA/H mice. Two of the virus preparations were associated with the development of early thymic lymphomas in SJL mice. None were lymphomagenic for mice of the CBA/H strain. We have proposed that genetic regulation of host immune response to viral proteins may explain these findings. (ERA citation 05:014288)