Nuclear-Based Methods for Analysis of Pollutants in Human Hair, Evaluation of the Significance of Elemental Deposition in Hair to Uptake and Distribution in the Body. Part of a Coordinated Programme on Nuclear Based Methods for An

摘要

This study attempts to correlate the level in hair of Cd, a major trace pollutant, vis-a-vis the element concentration in internal tissues and organs of experimental rats using the radioisotope tracer technique. In acute experiments rats were administered single i.v. injections of exp 109 Cd or sup(115m)Cd at different doses. In the chronic exposure experiments rats were fed inactive Cd as CdCl sub 2 and were later administered exp 109 Cd via i.v. injection at various intervals following the CdCl sub 2 supply. Synchronised hair cycles in rats were induced by plucking in both groups of experiments. Sections of hair were found to reflect the amount of Cd present in blood at the time of their growth, and this Cd level was proportional to the administered Cd dose. The study does not, however, show a direct relationship between the Cd level in hair and the respective element concentration in such critical organs as liver and kidneys. Under the conditions of chronic exposure the Cd content in hair was also observed to be proportional to the level of intake, and the significance of this proportionality appears to vary with the duration of exposure. (Atomindex citation 11:531255)